Public′s online attention to information about quitting smoking before and during COVID-19 pandemic: an analysis based on Baidu Index / 中华健康管理学杂志

Objective:To explore the hotspots of the public concerns about quitting smoking before and during the coronavirus disease 2019 (COVID-19) pandemic.Methods:The monthly search index data of four key words, “the harm of smoking”，“quitting smoking”，“passive smoking” and “electronic cigarette” before the COVID-19 (from January, 2016 to December, 2019) and during the COVID-19 (from January, 2020 to December, 2020) pandemic were manually collected from the Baidu Index platform. The one-way ANOVA was used to compare the differences among annual search indexes of four keywords. The linear regression model was used to test the annual linear trend of search index of each keyword before the COVID-19, and the one-sample t-test was used to analyze the differences of the search indexes during the COVID-19 and the means before the COVID-19. Results:During 2016—2020, the annual average search index of “electronic cigarette” was the highest (1.465 million), followed by “the harm of smoking” (0.884 million) and “quitting smoking” (0.780 million), while “passive smoking” was the lowest (0.171 million). Before the COVID-19 (2016—2019), the search index of each keyword had positive cumulative growth, but there was no significant linear trend of annual change ( P>0.05). During the COVID-19 period (2020), the search index of “the harm of smoking” decreased significantly (0.794 million vs 0.907 million, P=0.011), and “quitting smoking” (0.591 million vs 0.827 million, P=0.172) and “passive smoking” (0.164 million vs 0.172 million, P=0.257) showed a downward trend, while the search index of “electronic cigarettes” bucked the trend and increased significantly (1.825 million vs 1.375 million, P=0.010). Conclusions:The public′s online attention to “electronic cigarette” increases dramatically during COVID-19 along with other information about quitting smoking decreases. There are urgent needs for strengthening regulation and monitoring of electronic cigarettes and carrying out more effective publicity of scientific methods to help quit smoking.

Survey of exposure to second-hand smoke in residents aged 15 years and over one year after implementation of tobacco control regulation in public places in Beijing / 中华流行病学杂志

Objective@#To monitor the second-hand smoke (SHS) exposure in residents aged 15 years and over in public venues, indoor workplaces, on public transportation vehicles and at home in Beijing and evaluate the effect of Beijing Tobacco Control Regulation.@*Methods@#Data from 2014 and 2016 Beijing Adult Tobacco Survey were used. The surveys covered 16 districts in Beijing. The study subjects were selected through multi-stage cluster sampling with probability proportional to population size, and data were collected by using electronic questionnaire in face-to-face household interviews. A total of 8 484 and 9 372 valid questionnaires were collected for the surveys in 2014 and 2016, respectively. Statistical packages SPSS 20.0 and R 3.4.4 were used for data analyses. After weighting the samples using complex survey designs, the SHS exposure rates in different places in adults of Beijing were estimated. χ2 tests were performed for the comparison.@*Results@#The SHS exposure rates of residents aged 15 years and over in Beijing who visited health care facilities, government buildings, universities, primary and secondary schools and restaurants declined from 12.8%, 19.7%, 24.3%, 32.8% and 65.7% in 2014 to 6.2%, 10.8%, 12.5%, 19.1% and 32.5% in 2016, respectively. The SHS exposure rates in bars/nightclubs were 89.5% in 2014 and 80.3% in 2016. From 2014 to 2016, the SHS exposure rates declined from 35.7% to 20.0% in indoor workplaces and declined from 3.9% to 2.5% on public transportation vehicles. The SHS exposure rates at home were 39.8% in 2014 and 37.6% in 2016, respectively.@*Conclusions@#The SHS exposure rates in public places declined obviously in Beijing after the one year implementation of Beijing Tobacco Control Regulation, indicating the effect of the regulation implementation.

Implementation of Beijing Tobacco Control Regulation in restaurants in Dongcheng and Chaoyang districts of Beijing, 2018 / 中华流行病学杂志

Objective@#To evaluate the implementation effect of the Beijing Tobacco Control Regulation.@*Methods@#An observational study was conducted in a multi-stage randomly selected sample of 93 restaurants in Dongcheng and Chaoyang districts, Beijing. Undercover visits to the restaurants were paid by investigators at lunch or dinner time. The incidence of smoking behavior and the posters of no-smoking signs were observed, waiters were interviewed about awareness of the regulation, and comparisons with the baseline data of 6 months before and 1 month after regulation implementation were made.@*Results@#The pasting rate of no-smoking signs was 76.3%. The awareness of the regulation in the waiters surveyed was high. The incidence rate of smoking in restaurants (29.0%) was lower than that before the regulation implementation (36.7%), but it was significantly higher than that one month after regulation implementation (14.8%). No active interventions from the restaurant staff were observed when smoking occurred. The incidence of smoking in restaurants within commercial buildings (3.3%) was significantly lower than that in non-commercial buildings (41.3%), the difference was significant (P<0.05).@*Conclusions@#The effect of the regulation weakened 3 years after implementation compared with that in 1 month after the implementation. The enforcement degree of the regulation was conflicted with pasting rate of no-smoking signs and the regulation awareness level in waiters in restaurants in Dongcheng and Chaoyang districts.

One year after the implementation of 2015 Tobacco Control Regulation on persons aged 15 years and over tobacco use in Beijing / 中华流行病学杂志

Objective To understand the current status of smoking and smoking cessation in persons aged 15 years and over in Beijing and evaluate the effect of 2015 Beijing Tobacco Control Regulation.Methods In 2014 and 2016,based on the principles and methodology of the Global Adult Tobacco Survey.A total of 50 communities or townships were selected from 324 communities or townships in Beijing through multistage cluster sampling,and 2 community (village) committees from each community or township were selected with the method of probability proportional to size (PPS).A total of 100 surveillance sites were set,and 100 households were selected from each surveillance site by using simple random sampling.Data were collected through face-to-face interview from the eligible family members aged 15 years and over with the assistance of a tablet computen Statistical analyses were conducted by using complex sampling analyses module of SPSS 20.0,with weights as a combination of sampling weights,non-response weights and post-stratification weights,for the calculation of current smoking prevalence,daily smoking prevalence,smoking cessation rate,etc.Results A total of 8 484 and 9 372 valid questionnaires were obtained,respectively,in 2014 and 2016,with the response rate of 86.5％ and 96.5％.The current smoking prevalence in persons aged 15 years and over was 23.4％ in 2014,and 22.3％ in 2016.According to the 6th national census data,the current smoking population decreased by 199 000 in Beijing.The proportion of daily smokers declined from 20.7％ in 2014 to 19.2％ in 2016.The daily number of cigarettes consumed by current smokers increased from 14.6 in 2014 to 15.4 in 2016.The smoking cessation rate was 14.9％ in 2014 and 16.8％ in 2016.The proportion of current smokers who had at least one smoking cessation attempt in the past 12 months increased from 22.3％ in 2014 to 23.2％ in 2016,and the proportion of current smokers who planned to quit smoking increased from 11.6％ to 15.5％.Among the current smokers who had visited doctors in the past 12 months,the proportion of those having smoking cessation advice was 58.9％ in 2014 and 59.2％ in 2016.In 2016,among the current smokers who had attempted to quit in the past 12 months,36.8％ were aware of the smoking cessation clinics,and 29.5％were aware of the quitline.Among those who were aware,only 7.7％ had actually visited the cessation clinics,and 5.5％ had used the quitline.Conclusions After the implementation of 2015 Beijing Tobacco Control Regulation for 1 year,the current smoking prevalence in persons aged 15 years and over showed decreasing.It is necessary to further prompt the expansion of smoking cessation service to cover more current smokers.

One year after the implementation of 2015 Tobacco Control Regulation on persons aged 15 years and over tobacco use in Beijing / 中华流行病学杂志

Objective To understand the current status of smoking and smoking cessation in persons aged 15 years and over in Beijing and evaluate the effect of 2015 Beijing Tobacco Control Regulation.Methods In 2014 and 2016,based on the principles and methodology of the Global Adult Tobacco Survey.A total of 50 communities or townships were selected from 324 communities or townships in Beijing through multistage cluster sampling,and 2 community (village) committees from each community or township were selected with the method of probability proportional to size (PPS).A total of 100 surveillance sites were set,and 100 households were selected from each surveillance site by using simple random sampling.Data were collected through face-to-face interview from the eligible family members aged 15 years and over with the assistance of a tablet computen Statistical analyses were conducted by using complex sampling analyses module of SPSS 20.0,with weights as a combination of sampling weights,non-response weights and post-stratification weights,for the calculation of current smoking prevalence,daily smoking prevalence,smoking cessation rate,etc.Results A total of 8 484 and 9 372 valid questionnaires were obtained,respectively,in 2014 and 2016,with the response rate of 86.5％ and 96.5％.The current smoking prevalence in persons aged 15 years and over was 23.4％ in 2014,and 22.3％ in 2016.According to the 6th national census data,the current smoking population decreased by 199 000 in Beijing.The proportion of daily smokers declined from 20.7％ in 2014 to 19.2％ in 2016.The daily number of cigarettes consumed by current smokers increased from 14.6 in 2014 to 15.4 in 2016.The smoking cessation rate was 14.9％ in 2014 and 16.8％ in 2016.The proportion of current smokers who had at least one smoking cessation attempt in the past 12 months increased from 22.3％ in 2014 to 23.2％ in 2016,and the proportion of current smokers who planned to quit smoking increased from 11.6％ to 15.5％.Among the current smokers who had visited doctors in the past 12 months,the proportion of those having smoking cessation advice was 58.9％ in 2014 and 59.2％ in 2016.In 2016,among the current smokers who had attempted to quit in the past 12 months,36.8％ were aware of the smoking cessation clinics,and 29.5％were aware of the quitline.Among those who were aware,only 7.7％ had actually visited the cessation clinics,and 5.5％ had used the quitline.Conclusions After the implementation of 2015 Beijing Tobacco Control Regulation for 1 year,the current smoking prevalence in persons aged 15 years and over showed decreasing.It is necessary to further prompt the expansion of smoking cessation service to cover more current smokers.

Effects of waist-to-hip ratio on the detection rate of carotid artery plaque in the middle-aged and the elderly / 中国综合临床

Objective To investigate the effects of waist-to-hip ratio (WHR) on the formation of carotid plaque in the middle-aged and elderly people.Methods A total of five thousand and ninety-nine participants who have taken physical examination in Tangshan Kailuan Company from June 2010 to October 2011(above 40 years old,no previous history of ischemic stroke,transient ischemic attack,myocardial infarction) were enrolled in this study.Questionnaire survey,blood biochemical and carotid artery ultrasound examination were used to examine the subjects.According to WHR,quartile division was used to divide the subjects into four groups.The detection rates of carotid plaque among the 4 groups were compared.Multivariate logistic regression analysis was used to analyze the factors effecting carotid artery plaques.Results (1) The detection rate of carotid artery plaque increased with the increase of WHR,the rates of the first,second,third and fourth group were 20.7% (571/2 753),21.9% (604/2 753),27.5% (758/2 753) and 29.8% (820/2 753) respectively.The difference was statistically significant(P=0.000).(2) Logistic regression model was used to analyze multiple factors affecting the detection rate of carotid plaque.After the correction of other factors,compared with the first group,the carotid artery plaque detection rate in the second,third,fourth group were all increased,the OR values were 1.23(95%CI:1.10~1.54),1.65(95%CI:1.52~2.13),1.67(95%CI:1.54~2.17),respectively.Conclusion The increased WHR in the middle-aged and elderly population may increase the risk of carotid plaque formation.

Relationship between the waist-to-height ratio and the non-alcoholic fatty liver disease / 中国综合临床

Objective To analysis the relationship between of waist-to-height ratio(WHtR) and the non-alcoholic fatty liver disease(NAFLD).Methods A total of 7 896 were selected as observed subjects from the Kailuan Group in 2011-2012 health physical examination.A questionnaire survey,blood biochemical and abdominal ultrasound examination were finished by trained medical staff.According to previous study recommended cut points the observed subjects was divided into two groups:abdominnal obesity group(WHtR≥0.5,n=3 185) and non-abdominnal obesity group(WHtR<0.5,n=479).According to the WHtR and its quartile,the observed subjects was divided into four groups(first(WHtR<0.47),second(0.47≤WHtR<0.51),third(0.51≤WHtR<0.55) and forth(WHtR≥0.55) quartile groups).NAFLD detection rate of the four groups were Compared.Multiple Logistic regression analysis was used to analyze the influencing factors of the NAFLD.Results (1)The detection rate of NAFLD in abdominnal obesity group was higher than that in non-obesity group(62.7% vs.21.5%,P<0.01).Along with increasing WHtR level in the 4 quartile groups,the incidence of NAFLD was progressively increased,being 12.6 %,38.1%,57.5% and 72.5% respectively in the total population.After stratified by gender,15.1%,40.6%,59.6% and 75.0% in male,7.8%,31.5%,48.3% and 63.8% in female.In the same WHtR group,the NAFLD detection rate of male was higher than female,the differences were statistically significant(P<0.01).(2)Multiple logistic regression analysis showed that compared with the first quartile group,the second,third and forth quartile groups had increased risk of NAFLD after adjusting age,gender and other risk factors,the OR value being 3.19,5.93 and 9.81 in the total population.After adjusting above factors,the OR value being 3.12,6.02 and 10.45 in male,3.32,5.37 and 7.57 in female,respectively.Conclusion The incidence of NAFLD is increased along with the increasing the WHtR.

The relationship between the waist circumference level and the non-alcoholic fatty liver disease of the Kailuan Group population / 中华内分泌代谢杂志

_ Objective_ To explore the relationship between the waist circumference ( WC) level and the non-alcoholic fatty liver disease ( NAFLD) in the Kailuan Group population. Methods A total of 7 896 individuals were selected as observed subjects from the Kailuan Group in 2011-2012 health physical examination. A questionnaire survey, blood biochemical, and abdominal ultrasound examination were finished by trained medical staff. According to the WC measurement and its quartile in the health examination, the observed subjects were divided into four groups (first, second, third, and forth quartile groups). Multivariate logistic regression analysis was used to analyze the relationship between the WC level and the NAFLD. Results ( 1 ) The detection rate of NAFLD in central obesity groupwashigherthanthatinnon-obesitygroup(67.1% vs27.9%,P<0.01). AlongwithincreasingWClevelinthe 4 quartile groups, the incidences of NAFLD were progressively increased, being 7. 1%, 23. 4%, 33. 4%, and 36. 1%, respectively. In the total population, the detection rates were 18. 8%, 42. 5%, 62. 0%, and 76. 1% in males;5. 4%, 24. 1%, 44. 7% and 62. 9% in females. (2)Multivariate logistic regression analysis showed that WC is an independent risk factor after adjusting age, gender, and other risk factors, the OR value being 1. 08. It was also noticed that compared with the first quartile group, the second, third, and forth quartile groups had increased risk of NAFLD after adjusting above factors in different genders, with the OR values being 2. 74, 6. 59, and 11. 15 in males, while 2. 61, 5. 03, and 3. 67 in females, respectively. Conclusion WC was an independent risk factor for NAFLD;the incidence of NAFLD increased with increasing WC level in the Kailuan Group population.

The relationship between waist circumference and new-onset non-alcoholic fatty liver disease in non-obese patients with diabetes mellitus / 天津医药

Objective To investigate the relationship between waist circumference and new-onset non-alcoholic fatty liver disease in non-obese patients with diabetes mellitus. Methods A total of 1 950 patients with diabetes mellitus, who determined fasting plasma glucose(FPG)≥7.0 mmol/L or who were using hypoglycemic drugs and FPG90 cm (E group, n=421). Multiple Logistic regression model was used to analyze influential factors of new-onset non-alcoholic fatty liver disease in non-obese patients with diabetes mellitus. Re?sults The average duration of follow-up was(47.24±5.13) months. The incidence rate was 11.85%(231/1 950) in patients with non-alcoholic fatty liver disease. The incidence rates were 6.98%, 9.28%, 12.38%, 14.19%and 15.68%in A, B, C, D and E groups, and which were increased with the increased waist circumference (P<0.05). Results of multiple Logistic re?gression model analysis showed that compared with A group,OR values were 1.97 and 2.19 in D and E groups respectively (P<0.05). Conclusion Waist circumference≥85 cm was the risk factors of new-onset non-alcoholic fatty liver disease in non-obese patients with diabetes mellitus.

Effect of central obesity on the events of new-onset cerebral infarction among type 2 diabetes mellitus patients / 中华流行病学杂志

<p><b>OBJECTIVE</b>To analyze the effect of central obesity on new-onset cerebral infarction events among type 2 diabetes mellitus patients in the Kailuan Group.</p><p><b>METHODS</b>This was a prospective cohort study. In a total of 101 510 employees who had been carried out a healthy examination in Kailuan Group from Jul. 2006 to Oct. 2007. 8 306 type 2 diabetes mellitus patients were selected. According to the baseline waist measurement, the observed population was divided into two groups-with central obesity or without. The total period of follow-up was 38-53 (48.05 ± 3.09) months.</p><p><b>RESULTS</b>1) Mean age, BMI, the levels of SBP, DBP, pulse pressure, FPG, TC, LDL-C, uric acid significant increased in the central obesity group were higher than in the non-obese group (P < 0.01). 2) The incidence of new onset cerebral infarction in obese group was higher than that in the non-obese group (3.1% vs. 1.6%, 6.8%, P < 0.01; 3.3% vs. 1.7%, P < 0.01 in male respectively. 3) Results from the multiple logistic regression analysis showed that, compared with the non-obese group, the obese group had an increase of relative risk (RR) on new onset cerebral infarction events after adjustment on age, gender and other risk factors, with RR value as 2.07 (95%CI:1.39-3.09, P < 0.01).</p><p><b>CONCLUSION</b>Type 2 diabetes mellitus patients with central obesity seemed to have increased the risk of new-onset cerebral infarction events.</p>

On the relationship between the change in waist circumference and new onset of diabetes: Study on a population of Northern China / 中华内分泌代谢杂志

Objective To explore the relationship between the change in waist circumference (WC) and new onset diabetes (NOD) in a population of north China.Methods A total of 101510 subjects took part in the health examination from 2006 to 2007 for the employees of Kailuan Group.89364 subjects with fasting plasma glucose (FPG) ＜7.0 mmol/L,no history of diabetes,with complete data of FPG and WC,and without taking hypoglycemic agents were sclected as the observation cohort.Subjects who did not participate in the health examination from 2010 to 2011 and had incomplete data were finally excluded and thus 58426 subjects were included for final analysis.According to the baseline WC measurement and its quartile in the health examination during 2006 to 2007,the observed population was divided into two groups (obese group and non-obese group) or four groups ( first,second,third,and forth quartile groups).Multiple logistic regression analysis was used to test the relation between the change in WC and NOD.Results ( 1 ) The incidence of NOD in obese group was higher than that in non-obese group (8.02％ vs 3.37％,P＜0.01 ).Along with increasing WC in the 4 quartile groups,the incidence of NOD was progressively increased,being 2.32％,3.62％,5.46％,and 8.89％ respectively in the total population ( 2.84％,3.65％,5.32％,and 8.95％ in male,and 1.50％,3.41％,6.22％,and 8.51％ in female).( 2 ) Multiple logistic regression analysis showed that compared with the first quartile group,the second,third,and forth quartile groups had increased risks of NOD after adjusting age,gender,and other risk factors,the OR value being 1.17,1.47,and 1.95,respectively.After adjusting above factors in different genders,the influence of the second group on NOD in males and females was not significant,however,they still increased the risks of NOD,with the OR value being 1.08,1.36,and 1.90 in male,and 1.35,1.70,and 1.88 in female,respectively.Conclusion The incidence of NOD is increased with increasing WC.

The relationship between fasting plasma glucose level and first cerebral infarction event in the population with diabetes / 中华内分泌代谢杂志

ObjectiveTo study the relationship between fasting plasma glucose (FPG) level and the first cerebral infarction event in the population with diabetes.Methods This was a prospective cohort stndy.8 306 diabetic subjects who determined FPG ≥ 7.0 mmol/L or treated with insulin or hypoglycemic drugs and FPG ＜7.0 mmool/L as the observation population and were followed-up for (48.01 ± 3.14) months.During the course,cerebral infarction events were determined every 6 months.Results( 1 ) By the end of following-up,with the increasing levels of the baseline FPG,the total cholesterol (TC),triglyceride (TG) levels were gradually increased in the diabetic population,the differences were significant [ TC:( 4.93 ± 1.15,5.10 ± 1.20,5.15 ± 1.28,5.33 ± 1.35 ) mmol/L,TG:( 1.70 ± 1.26,1.83 ± 1.29,2.18 ± 1.76,2.41 ± 2.08 ) mmol/L,P＜0.05 ] ; the plasma low density lipoprotein-cholesterol (LDL-C),systolic blood pressure ( SBP),diastolic blood pressure ( DBP),and body mass index (BMI) levels were also increased significantly ( P＜0.05 ).(2) The ineidence of cerebral infarction event in the group of patients with 7.0 mnol/L ≤ FPG ＜ 9.0 mmol/L was the lowest,the differences were significant ( 2.1％,P ＜0.01 ).Compared with the group of 7.0 mmol/L≤ FPG＜9.0 mmol/L,after adjusting for age,sex,BMI,SBP,DBP,TC,TG,low density lipoprotein-cholesterol,high density lipoprotein-cholesterol,smoking,diabetic duration and treatment,the relative risk for cerebral infarction events were 1.85 (95％ CI 1.09-3.15,P＜0.05) and 1.54 (95％CI 1.16-2.05,P ＜ 0.01 ) for those groups with 6.1 mmol/L ≤ FPG ＜ 7.0 mmol/L and FPG ≥ 9.0 mmol/L respectively.ConclusionThe risk of new in cidence of cerebral infarction events seems to be the lowest in the group of diabetic patients whose FPGs are wihin 7.0-9.0 mmol/L range.

Level and influential factors of serum high-sensitivity C-reactive protein in new-onset diabetic population / 中华内分泌代谢杂志

The level of serum high-sensitivity C-reactive protein (hsCRP) in the population with new-onset diabetes was detected and its influential factors were analyzed.The concentrations of hsCRP increased with age in the population with new-onset diabetes( Ptrend＜0.01 ).The percentage of subjects with hsCRP levels ＞3 mg/L was 18.8％in men and 26.7％ in women.A logistic regression analysis indicated that age,gender,body mass index,waist circumference,fasting plasma glucose,and triglyceride were the influential factors of hsCRP levels in diabetic population( P＜0.05 or P＜0.01 ).A variety of cardiovascular factors affected hsCRP level and a strong association existed between hsCRP and abdominal obesity.

Later course accelerated hyperfractionated radiotherapy combined with chemotherapy for advanced nasopharyngeal carcinoma / 肿瘤研究与临床

Objective To evaluate the treatment effect of later course accelerated hyperfractionated radiotherapy with chemotherapy for stage Ⅲ and ⅣA nasopharyngeal carcinoma. Methods 116 patients with stage Ⅲand Ⅳ s nasopharyngeat carcinoma were randomly divided into three groups: the conventional fractionation radiotherapy(CFR, 38 cases), the concurrent radiochemotherapy group(CCRT, 39 cases) and the later course accelerated hyperfractionated radiotherapy combined with chemotherapy group (LCAF+CT, 39cases). CFR group was treated with 60Co γ rays and X rays. When the patients had received the dose of 36～38 Gy through composite faciocervical fields, changed into preauricular fields, the total dose was 70 ～75 Gy.And the total dose of cervical metastasis lymph nodes were 70～80 Gy. CCRT group was treated with DDP and 5-Fu. LCAF+CT group was treated with accelerated hyperfractionated radiotherapy. When the dose of composite faciocervical fields had reached 36～38 Gy, changed the fields and treated with accelerated hyperfractionated radiotherapy, 1.3 Gy/fraction, twice daily. The total dose was 69.8～75 Gy. And the chemotherapy drugs was similar to CCRT group. Results The positive response rate among LCAF+CT, CCRT and CFR groups were 94.9 %, 89.7 %, 76.3 % respectively. The complete response rate in the nasopharyn of LCAF+CT group was higher than CFR group(P ＜0.05). The local control rates of one, two and three year of three groups were 100 %, 97.4 %, 89.5 %, 94.9 %, 84.6 %, 68.4 % and 89.7 %, 74.4 %, 57.9 %respectively; and the survival rates of one, two and three year of three groups were 100 %, 92.3 %, 84.2 %;89.7 %, 84.6 %, 71.0 % and 79.5%, 76.9 %, 57.9 % respectively. There were obvious difference between LCAF+CT and CCRT groups in local control rate and survival rate. But there were no difference between LCAF+CT group and CCRTgroup, and also between CCRT group and CFR group. Conclusion The later course accelerated hyperfraetionated radiotherapy combined with chemotherapy can promote disappearance of primary lesion and improve the local control rate and survival rate of patients with stage Ⅲand ⅣA nasopharyngeal carcinoma.

Effect of Entecavir Combined with Dahuangzhechong Pills on Hepatic Fibrosis in Patients with Chronic Hepatitis B / 中国药房

0.05).After treatment,serum hyaluronic acid(HA),laminin(LN),type Ⅲ precollagen,type Ⅳ collagen peptide decreased more significantly in the treatment group than in the control group(P

Clinical Observation of Chitosan in the Prevention of Re-adhesion after Hydrotubation / 中国药房

OBJECTIVE:To observe the effects of adding chitosan in the hydrotubation on increasing conception rates.METHODS:184tubal infertility cases were divided into2groups at random,the95cases in the treatment group were injected with0.3%chitosan solution10ml after the routine hydrotubation;89cases in the control group were only given the conven-tional hydrotubation.RESULTS:The conception rates for the treatment group and the control group were40.7%and24.4%respectively within6months after hydrotubation(P

Anti-tumor effect of Haishengsu extracted from Tegillarca granosa in vitro and in vivo / 中国海洋药物

Aim To study the infuences of Haishengsu extracted from Tegillarca granosa on cultured tumor cells of lung cancer, breast cancer and carcinoma of stomach from human in vitro and its preventive antitumor effect on transplanted tumor in mice in vivo. Methods The inhibitory effect of Haishengsu on tumor cells proliferation was assayed by MTT method, and transplant tumor models of sarcoma 180 (S 180), Ehrlich ascites carcinoma (EAC), and hepatoma (Heps) were used. Before and after transplantation, different doses of Haishengsu were given to the mice for 10 days. The inhibition rates and life span of the mice were calculated. Results Haishengsu at concentrations of 0.5%～2.0% inhibited the proliferation of tested tumor cells in vitro,especially on lung cancer cells with a dose dependent manner (r= 0.974,P